Protein Details: Store-operated calcium entry-associated regulatory factor
Protein ID
ICDB_Pro_0126
Protein Name
Store-operated calcium entry-associated regulatory factor
Gene Name
saraf; tmem66; zgc:153286
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Length
345 amino acids
AlphaFoldDB
AF-F1QPC3-F1-model_v4.pdb
Function
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling; promotes a slow inactivation of STIM (stim1 or stim2)-dependent SOCE activity (By similarity).
Sequence
MRVSGALFLQFLLLVVPHISCWNDEAVLLRDVQVLTLYRGRYTTARRSSPVPQLQCIGGSAGCGSFTPEVVQCYNRGSDGIDAQWECKADMDNLYRFGRVEVSCEGYNSPNDAYVLRGSCGLEYTLELTAEGKQQQGSSGFSGFASNFFQGFSNQKQQQRGGGGDGGGPYQQHSYQNSPSGDGVGGLLVVAFLLLVAFVVYKMFLCSPTNGHQGFGGDQGYDSTNGAWDNSQGMGPPPPGFKPDYYSGDHSNSRPGYGFSDSYTRPQSSWTGFTGRTRPGGGGGGGGGFWTGMGTGGILGYLFGNQRRQPPMGFAGPTYNSNPSPAPKTSSGTRTASGFGTTKRR
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/nature12111
RefSeq
NP_001070057.1